Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus
Yong Jian-ping; Lv Qiao-ying; Aisa Haji Akber; Aisa, HA
2009
发表期刊BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN0253-2964
卷号30期号:2页码:435-440
摘要19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a similar to 21, 3a similar to 3g were syntliesized and preliminarily evaluated in vitro against influenza virus A(3),B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus A(3)(TC50 = 120.6 mu mol/L, IC50 = 19.2 mu mol/L, SI = 6.3) and B(TC50 = 120.6 mu mol/L, IC50 = 29.9 mu mol/L, SI = 4.0); 2g was more active against influenza A(3) virus at very low cytotoxicity (TC50 > 2092.1 mu mol/L, IC50 = 143.7 mu mol/L, SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 (TC50 = 200.0 mu mol/L, IC50 = 11.3 mu mol/L, SI = 17.7) and HSV-2 (TC50 = 200.0 mu mol/L, IC50 = 20.7 mu mol/L, SI = 9.7).
关键词Synthesis Rupestonic Acid Amide Derivative Anti-viral Activities
学科领域Chemistry
收录类别SCI
WOS记录号WOS:000264903700033
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/1888
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber,et al. Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2009,30(2):435-440.
APA Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber,&Aisa, HA.(2009).Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,30(2),435-440.
MLA Yong Jian-ping,et al."Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A(3),B and Herpes Simplex Type 1 and 2 Virus".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 30.2(2009):435-440.
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