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学科主题: Chemistry
题名: synthesis of (5r,8r)-2-(3,8-dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) acrylic acid (rupestonic acid) amide derivatives and in vitro inhibitive activities against influenza a(3),b and herpes simplex type 1 and 2 virus
作者: Yong Jian-ping; Lv Qiao-ying; Aisa Haji Akber
通讯作者: Aisa, HA
关键词: Synthesis ; Rupestonic acid amide derivative ; Anti-viral activities
刊名: BULLETIN OF THE KOREAN CHEMICAL SOCIETY
发表日期: 2009
卷: 30, 期:2, 页:435-440
收录类别: SCI
资助者: National Nature and Science Fundation
摘要: 19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a similar to 21, 3a similar to 3g were syntliesized and preliminarily evaluated in vitro against influenza virus A(3),B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus A(3)(TC50 = 120.6 mu mol/L, IC50 = 19.2 mu mol/L, SI = 6.3) and B(TC50 = 120.6 mu mol/L, IC50 = 29.9 mu mol/L, SI = 4.0); 2g was more active against influenza A(3) virus at very low cytotoxicity (TC50 > 2092.1 mu mol/L, IC50 = 143.7 mu mol/L, SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 (TC50 = 200.0 mu mol/L, IC50 = 11.3 mu mol/L, SI = 17.7) and HSV-2 (TC50 = 200.0 mu mol/L, IC50 = 20.7 mu mol/L, SI = 9.7).
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1888
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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synthesis of (5r,8r)-2-(3,8-dimethyl-2-oxo-1,alpha-octahydroazulen-5-yl) acrylic acid (rupestonic acid) amide derivatives and in vitro inhibitive activities against influenza a(3),b and herpes simplex type 1 and 2 virus.pdf(284KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Yong Jian-ping,Lv Qiao-ying,Aisa Haji Akber. synthesis of (5r,8r)-2-(3,8-dimethyl-2-oxo-1,2,4,5,6,7,8,8 alpha-octahydroazulen-5-yl) acrylic acid (rupestonic acid) amide derivatives and in vitro inhibitive activities against influenza a(3),b and herpes simplex type 1 and 2 virus[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2009,30(2):435-440.
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文件名: synthesis of (5r,8r)-2-(3,8-dimethyl-2-oxo-1,alpha-octahydroazulen-5-yl) acrylic acid (rupestonic acid) amide derivatives and in vitro inhibitive activities against influenza a(3),b and herpes simplex type 1 and 2 virus.pdf
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