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学科主题: Chemistry
题名: synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses
作者: Yong Jianping; Aisa Haji Akber; Nie Lifei
关键词: synthesis ; rupestonic acid ester derivative ; influenza virus ; herpes simplex virus ; biological activity
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2009
卷: 29, 期:10, 页:1640-1644
收录类别: SCI
摘要: To improve rupestonic acid biological activities, ten rupestonic acid benzyl ester derivatives were synthesized in the presence of DCC/DMAP with the rupestonic acid and substituted benzyl alcohol as starting materials. The synthesized compounds 2a similar to 2j were confirmed by the methods of IR, (1)H NMR, ESI-MS and preliminarily assayed in vitro against influenza viruses A3, B and herpes simplex virus I (HSV-I), herpes simplex virus II (HSV-II). The results showed that most of the synthesized compounds had distinct inhibition against influenza viruses, 2e exhibited in vitro inhibitory activity against both influenza A3 and B viruses with IC(50) values of 5.5, 5.5 mu mol/L, respectively, and 2i showed higher activity against influenza A virus with an IC(50) value of 7.8 mu mol/L. Therefore, compounds 2e, 2i can be as lead compounds for anti-flu agent. Most of the compounds showed higher inhibition against HSV-I and HSV-II viruses at 0.1 mu g/mL concentration.
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1875
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Yong Jianping,Aisa Haji Akber,Nie Lifei. synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2009,29(10):1640-1644.
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文件名: synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses.pdf
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