Two novel elemanolide dimers, vernodalidimers A (1) and B (2), possessing a rare tricyclic ortho ester moiety, were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by 1D and 2D NMR data and CD spectra. Vernodalidimers A (1) and B(2) exhibited potent cell growth inhibitory activity against HL-60 cells (IC(50) 0.72 and 0.47 mu M, respectively).
Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Xinjiang, Peoples R China;Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan;Tokushima Bunri Univ, Fac Pharmaceut Sci, Sanuki City, Kagawa 7692193, Japan
Liu Yongqiang,Nugroho Alfarius E.,Hirasawa Yusuke,et al. Vernodalidimers A and B, novel orthoester elemanolide dimers from seeds of Vernonia anthelmintica[J]. TETRAHEDRON LETTERS,2010,51(50):6584-6587.