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ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN
Xin Xuelei; Wang Qi; Aisa Haji Akber; Wang Hanqing
2010
Source PublicationJournal of Food Biochemistry
ISSN0145-8884
Volume34Issue:4Pages:811-824
Abstract

Nigella glandulifera Freyn, an annual plant species of the family Ranunculaceae, served as a traditional Uigur medicine and food. Many researchers have reported that Nigella sativa L., which is the same genus with it, has an antidiabetic effect, the seeds oil was an activity component used as a kind of function food. In the present study, the difference of oil extract between n-hexane and petroleum ether respectively from the seeds of Nigella glandulifera Freyn were analyzed by gas chromatography-mass spectrometry, all of them can inhibit protein tyrosine phosphatase 1B (PTP1B) with half maximal inhibitory concentration values of 33.15 ± 0.77 and 18.50 ± 0.52 μg/mL, respectively. They have different binding sites with PTP1B. Lastly, inhibited ability of PTP1B and that of TCPTP were compared; all of them have shown some selectivity.

Subject AreaBiochemistry & Molecular Biology ; Food Science & Technology
DOI10.1111/j.1745-4514.2009.00318.x
Indexed BySCI
WOS IDWOS:000280643000008
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/1823
Collection资源化学研究室
Corresponding AuthorAisa Haji Akber
Affiliation1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Xin Xuelei,Wang Qi,Aisa Haji Akber,et al. ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN[J]. Journal of Food Biochemistry,2010,34(4):811-824.
APA Xin Xuelei,Wang Qi,Aisa Haji Akber,&Wang Hanqing.(2010).ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN.Journal of Food Biochemistry,34(4),811-824.
MLA Xin Xuelei,et al."ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN".Journal of Food Biochemistry 34.4(2010):811-824.
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