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学科主题: Pharmacology & Pharmacy ; Chemistry
题名: protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats
作者: Xue Mei; Jiang Zhen-Zhou; Wu Tao; Tan Ming; Liu Ji-Ping; Mu Xian-Min; Su Yu-Wen; Zhang Lu-Yong
关键词: Computer-assisted sperm analysis ; Rats, male reproductive toxicity ; Solid lipid nanoparticles ; Testis ; Tripterygium glycoside
刊名: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
发表日期: 2011
卷: 61, 期:10, 页:571-576
收录类别: SCI
资助者: Ministry of Finance 200707008; Megaprojects of Science Research for the 11th Five-Year Plan: Standardized Platform Construction and Scientific Application in New Technologies for New Drug Screening 2009ZX09302-002
摘要: The protective effects of tripterygium glycoside-loaded solid lipid nanoparticles (TG-SLNs) on male reproductive toxicity were investigated in rats. Thirty-six male Sprague-Dawley rats were randomly divided into three groups of 12: control group, tripterygium glycoside (TG) group, and TG-SLN group. After the animals had been orally administered with the substances for 28 consecutive days, their sperm count and sperm motility, organ coefficients, serum testosterone levels, testicular ultrastructure, and reproductive ability were observed. The results showed that the sperm motility rate in the TG group was only 3%, whereas the rates in the TG-SLN and control groups were 33 % and 71%, respectively. Compared with those in the control group, the motion counts of path velocity, track speed, progressive velocity, straightness, linearity, beat cross frequency, amplitude of lateral head displacement, and sperm concentrations in the TG-SLN group were not significantly different while those in the TG group significantly decreased (p < 0.01). TG-SLNs did not cause testicular atrophy and instead maintained normal serum testosterone levels. The effect of TG-SLNs on the testicular ultrastructure was very evident; the morphologies of Sertoli, spermatogonial, mitochondrial, and sperm cells were normal. In terms of reproductive ability, one rat (17%) from the TG-SLN group and five rats (83%) from the control group became pregnant, whereas none of the rats from the TG group became pregnant. These data indicate that TG-SLNs have potentially protective effects on male reproductive toxicity in rats.
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1677
Appears in Collections:资源化学研究室_期刊论文

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作者单位: China Pharmaceut Univ, Jiangsu Ctr Drug Screening Lab, Nanjing 210009, Jiangsu Provinc, Peoples R China;China Pharmaceut Univ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu Provinc, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi, Peoples R China;Shanxi Univ Chinese Med, Dept Pharmacol, Xianyang, Shanxi Province, Peoples R China

Recommended Citation:
Xue Mei,Jiang Zhen-Zhou,Wu Tao,et al. protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats[J]. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,2011,61(10):571-576.
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