Three-component coupling reactions of sulfonylimidates, silyl glyoxylates and N-tert-butanesulfinyl aldimines efficiently provide cyclic N-sulfonylamiclines containing free endocyclic N-H. The formation of two C-C bonds (contiguous stereogenic carbons), one O-Si bond, and one C-N bond, together with the cleavage of the chiral auxiliary (tert-butanesulfinyl group), occurs with excellent chemoselectivity, diastereoselectivity, and enantioselectivity in this one-pot cascade transformation.
three component reactions of sulfonylimidates silyl glyoxylates and n-tert-butanesulfinyl aldimines an efficient diastereoselective and enantioselective synthesis of cyclic n sulfonylamidines.pdf（738KB）
Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Univ, Urumqi 830011, Peoples R China
Yao Ming,Lu Chong-Dao. Three-Component Reactions of Sulfonylimidates, Silyl Glyoxylates and N-tert-Butanesulfinyl Aldimines: An Efficient, Diastereoselective, and Enantioselective Synthesis of Cyclic N-Sulfonylamidines[J]. ORGANIC LETTERS,2011,13(10):2782-2785.