One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions
Li Xinzhong; Lin Qi; Eli Wumanjiang
2011
发表期刊CHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN0253-2786
卷号31期号:6页码:855-859
摘要

Two novel Bronsted acidic ionic liquids 1-(4-sulfonic)-benzyl-3-methylimidazolium hydrogen sulfate (a) and 1-(4-sulfonic)-benzyl-3-methylpyridium hydrogen sulfate (b) were used as catalyst and medium in the one-pot synthesis of 3-substituted-4(3H)-quinazolinones, using anthranilic acid, triethyl orthoformate or formic acid and aromatic or aliphatic amines as starting materials under microwave irradiation. It was found that the reactions completed within 4 similar to 6 min with good to excellent yields (74 similar to 94%) in the presence of 10 mol% ionic liquids. The ionic liquids can be recovered easily and recycled three times without any significant loss in catalytic activity. This synthetic method has the advantage of generality. The aromatic or aliphatic substituents can be introduced in the 3-position, the substrates with electron-withdrawing substituents can also take part of the reaction smoothly and offered satisfactory yields. In addition to, this synthetic method can use 85% formic acid directly with yields of 72%similar to 91%.

关键词Bronsted Acid Ionic Liquid Multi-component
学科领域Chemistry
收录类别SCI
WOS记录号WOS:000292582000012
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/1660
专题新疆维吾尔自治区精细化工工程技术研究中心
作者单位Minjiang Univ, Dept Chem & Chem Engn, Fuzhou 350108, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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Li Xinzhong,Lin Qi,Eli Wumanjiang. One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(6):855-859.
APA Li Xinzhong,Lin Qi,&Eli Wumanjiang.(2011).One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions.CHINESE JOURNAL OF ORGANIC CHEMISTRY,31(6),855-859.
MLA Li Xinzhong,et al."One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions".CHINESE JOURNAL OF ORGANIC CHEMISTRY 31.6(2011):855-859.
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