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学科主题: Neurosciences & Neurology
题名: Effects of Gossypium herbaceam Extract Administration on the Learning and Memory Function in the Naturally Aged Rats: Neuronal Niche Improvement
作者: Liu Yanyong; Aisa Haji Akber; Ji Chao; Yang Nan; Zhu Haibo; Zuo Pingping
关键词: Aging ; Alzheimer's disease ; mild cognitive impairment ; oxidative stress
刊名: JOURNAL OF ALZHEIMERS DISEASE
发表日期: 2012
DOI: 10.3233/JAD-2012-112153
卷: 31, 期:1, 页:101-111
收录类别: SCI
资助者: National Natural Sciences Foundation of China (NSFC) 30873063, 30973527, 308101070, 81050025; National 973 Fundamental Project of China 2007CB507404, 2010CB934002; Natural Sciences Foundation of Beijing 7092068, 7102115; National ST Major Project 2009ZX09103-034, 2009ZX09301-003, 2009ZX09303-003, 2008ZX09401, 2009ZX09311-004
摘要: Aging-associated cognitive impairment is an important health care issue since individuals with mild cognitive impairment are more likely to develop Alzheimer's disease. In the present study, the protective effect of Gossypium herbaceam extracts (GHE) on learning and memory impairment associated with aging were examined in vivo using Morris water maze and step through task. Furthermore, the antioxidant activity and neuroprotective effect of GHE was investigated with methods of histochemistry and biochemistry. These data showed that oral administration with GHE at the doses of 35, 70, and 140 mg/kg exerted an improved effect on the learning and memory impairment in aged rats. Subsequently, GHE afforded a beneficial action on eradication of free radicals without influence on the activity of glutathione peroxidase and superoxide dismutase. GHE treatment enhanced the expression levels of nerve growth factor. Meanwhile, proliferation of neural progenitor cells was elevated in hippocampus after treatment with GHE. Taken together, neurogenic niche improvement could be involved in the mechanism underlying neuroprotection of GHE against aging-associated cognitive impairment. These findings suggested that GHE might be a potential agent as cognitive-enhancing drugs that delay or halt mild cognitive impairment progression to Alzheimer's disease or treatment of aging-associated cognitive impairment.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1646
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Peking Union Med Coll, Dept Pharmacol, Inst Basic Med Sci, Beijing 100005, Peoples R China;Chinese Acad Med Sci, Dept Pharmacol, Inst Basic Med Sci, Beijing 100005, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China;Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China; Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Liu Yanyong,Aisa Haji Akber,Ji Chao,et al. Effects of Gossypium herbaceam Extract Administration on the Learning and Memory Function in the Naturally Aged Rats: Neuronal Niche Improvement[J]. JOURNAL OF ALZHEIMERS DISEASE,2012,31(1):101-111.
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