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学科主题: Chemistry
题名: Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B
作者: Zhao Jiangyu; Aisa Haji Akber
通讯作者: Zhao, JY
关键词: rupestonic acid ; isoxazole derivative ; influenza virus ; inhibitory activity
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2012
DOI: 10.6023/cjoc1108081
卷: 32, 期:2, 页:333-337
收录类别: SCI
摘要: To improve biological activity of rupestonic acid, six rupestonic acid amide derivatives containing isoxazole were synthesized in the presence of DCC, HOBt/DMAP using the rupestonic acid and 3-aryl-5-isoxazole-methylamine as the starting materials. The synthesized compounds 3a similar to 3f were confirmed by the methods of H-1 NMR, C-13 NMR, IR, ESI-MS techniques and preliminarily assayed in vitro against influenza viruses A and B. The results showed that compound 3c showed better activity against both influenza viruses A (H3N2) and B, and compounds 3c and 3e had the higher inhibition against influenza B virus than the parent compound 1.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1641
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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新型一枝蒿酮酸异噁唑衍生物的合成及其抗A_B型流感病毒活性研究.pdf(824KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Zhao Jiangyu,Aisa Haji Akber. Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(2):333-337.
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文件名: 新型一枝蒿酮酸异噁唑衍生物的合成及其抗A_B型流感病毒活性研究.pdf
格式: Adobe PDF
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