Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B
Zhao Jiangyu; Aisa Haji Akber; Zhao, JY
2012
发表期刊CHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN0253-2786
卷号32期号:2页码:333-337
摘要To improve biological activity of rupestonic acid, six rupestonic acid amide derivatives containing isoxazole were synthesized in the presence of DCC, HOBt/DMAP using the rupestonic acid and 3-aryl-5-isoxazole-methylamine as the starting materials. The synthesized compounds 3a similar to 3f were confirmed by the methods of H-1 NMR, C-13 NMR, IR, ESI-MS techniques and preliminarily assayed in vitro against influenza viruses A and B. The results showed that compound 3c showed better activity against both influenza viruses A (H3N2) and B, and compounds 3c and 3e had the higher inhibition against influenza B virus than the parent compound 1.
关键词Rupestonic Acid Isoxazole Derivative Influenza Virus Inhibitory Activity
学科领域Chemistry
DOI10.6023/cjoc1108081
收录类别SCI
WOS记录号WOS:000301616200011
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/1641
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Zhao, JY
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Zhao Jiangyu,Aisa Haji Akber,Zhao, JY. Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(2):333-337.
APA Zhao Jiangyu,Aisa Haji Akber,&Zhao, JY.(2012).Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(2),333-337.
MLA Zhao Jiangyu,et al."Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.2(2012):333-337.
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