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Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)
Senejoux Francois; Demougeot Celine; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Girard-Thernier Corine
2012
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume83Issue:2Pages:377-382
AbstractZiziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in part, by phenolic components.
KeywordUighur Traditional Medicine Ziziphora Clinopodioides Lam. Bioassay-guided Fractionation Rat Aortic Rings Vasorelaxant Phenolic Compounds
Subject AreaPharmacology & Pharmacy
DOI10.1016/j.fitote.2011.11.023
Indexed BySCI
WOS IDWOS:000300817000020
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/1637
Collection省部共建新疆特有药用资源利用重点实验室
AffiliationUniv Franche Comte, EA 4267, UFR Sci Med & Pharmaceut, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, France;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China
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Senejoux Francois,Demougeot Celine,Kerram Parhat,et al. Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)[J]. FITOTERAPIA,2012,83(2):377-382.
APA Senejoux Francois.,Demougeot Celine.,Kerram Parhat.,Aisa Haji Akber.,Berthelot Alain.,...&Girard-Thernier Corine.(2012).Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae).FITOTERAPIA,83(2),377-382.
MLA Senejoux Francois,et al."Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)".FITOTERAPIA 83.2(2012):377-382.
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