Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)
Senejoux Francois; Demougeot Celine; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Girard-Thernier Corine
2012
发表期刊FITOTERAPIA
ISSN0367-326X
卷号83期号:2页码:377-382
摘要Ziziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in part, by phenolic components.
关键词Uighur Traditional Medicine Ziziphora Clinopodioides Lam. Bioassay-guided Fractionation Rat Aortic Rings Vasorelaxant Phenolic Compounds
学科领域Pharmacology & Pharmacy
DOI10.1016/j.fitote.2011.11.023
收录类别SCI
WOS记录号WOS:000300817000020
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/1637
专题省部共建新疆特有药用资源利用重点实验室
作者单位Univ Franche Comte, EA 4267, UFR Sci Med & Pharmaceut, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, France;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China
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Senejoux Francois,Demougeot Celine,Kerram Parhat,et al. Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)[J]. FITOTERAPIA,2012,83(2):377-382.
APA Senejoux Francois.,Demougeot Celine.,Kerram Parhat.,Aisa Haji Akber.,Berthelot Alain.,...&Girard-Thernier Corine.(2012).Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae).FITOTERAPIA,83(2),377-382.
MLA Senejoux Francois,et al."Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)".FITOTERAPIA 83.2(2012):377-382.
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