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学科主题: Pharmacology & Pharmacy
题名: Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)
作者: Senejoux Francois; Demougeot Celine; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Girard-Thernier Corine
关键词: Uighur traditional medicine ; Ziziphora clinopodioides Lam. ; Bioassay-guided fractionation ; Rat aortic rings ; Vasorelaxant ; Phenolic compounds
刊名: FITOTERAPIA
发表日期: 2012
DOI: 10.1016/j.fitote.2011.11.023
卷: 83, 期:2, 页:377-382
收录类别: SCI
资助者: Region Franche-Comte; French Ministry of Foreign and European Affairs
摘要: Ziziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in part, by phenolic components.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1637
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Univ Franche Comte, EA 4267, UFR Sci Med & Pharmaceut, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, France;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China

Recommended Citation:
Senejoux Francois,Demougeot Celine,Kerram Parhat,et al. Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)[J]. FITOTERAPIA,2012,83(2):377-382.
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文件名: bioassay-guided isolation of vasorelaxant compounds from ziziphora clinopodioides lam. (lamiaceae).pdf
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