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学科主题: Chemistry
题名: Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of Euphorbia macrorrhiza
作者: Lin Jianbo; Dou Jun; Xu Jiangling; Aisa Haji Akber
通讯作者: Aisa, HA
关键词: Euphorbia macrorrhiza ; essential oil composition ; antimicrobial activity ; antitumor activity
刊名: MOLECULES
发表日期: 2012
DOI: 10.3390/molecules17055030
卷: 17, 期:5, 页:5030-5039
收录类别: SCI
资助者: China National Funds for Distinguished Young Scientists 30925045; CAS/SAFEA International Partnership Program for Creative Research Teams
摘要: The present study aimed to examine the chemical composition and biological activity of essential oils extracted from Euphorbia macrorrhiza collected from Northwest China. The major constituents of the essential oils of aerial parts and roots of E. macrorrhiza are acorenone B (16.72% and 25.80%), (+)-cycloisosativene (14.94% and 12.40%), 3a-hydroxy-5b-androstane (10.62% and 5.52%), copaene (7.37% and 6.29%), l-calamenene (4.13% and 4.65%) and beta-cedrene (8.40% and 7.98%), respectively. The minor components of them are thymene, gamma- terpinene, thymecamphor, alpha-cedrene, zingiberene, trans-caryophyllene, beta- chamigrene, curcumene, pentadecane, (-)-alpha-muurolene, cuparene, gamma-cadinene, (Z)-3-heptadecene, 1,3,7,7-tetramethyl-2-oxabicyclo(4.4.0)dec-5-en-4-one, hexahydrofarnesyl acetone, gamma- elixene and palmitinic acid. The antimicrobial and antitumor activitiy of the E. macrorrhiza essential oil against Staphyloccocus aureus, Escherichia coli, Canidia Albicans and Caco-2 cells were evaluated. Among all the tested microorganisms and Caco-2 cells, the essential oils showed the strongest inhibitory effect on Staphyloccocus aureus (MIC = 2.8 mu g/mL) and Caco-2 cell (IC50 = 11.86 mu g/mL), whereas no effect on Escherichia coli and Candida albicans. The data of this study suggested that the E. macrorrhiza essential oils have great potential as a natural medicine for microbial infections and cancers.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1628
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Lin Jianbo,Dou Jun,Xu Jiangling,et al. Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of Euphorbia macrorrhiza[J]. MOLECULES,2012,17(5):5030-5039.
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