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Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of Euphorbia macrorrhiza
Lin Jianbo; Dou Jun; Xu Jiangling; Aisa Haji Akber; Aisa, HA
2012
Source PublicationMOLECULES
ISSN1420-3049
Volume17Issue:5Pages:5030-5039
AbstractThe present study aimed to examine the chemical composition and biological activity of essential oils extracted from Euphorbia macrorrhiza collected from Northwest China. The major constituents of the essential oils of aerial parts and roots of E. macrorrhiza are acorenone B (16.72% and 25.80%), (+)-cycloisosativene (14.94% and 12.40%), 3a-hydroxy-5b-androstane (10.62% and 5.52%), copaene (7.37% and 6.29%), l-calamenene (4.13% and 4.65%) and beta-cedrene (8.40% and 7.98%), respectively. The minor components of them are thymene, gamma- terpinene, thymecamphor, alpha-cedrene, zingiberene, trans-caryophyllene, beta- chamigrene, curcumene, pentadecane, (-)-alpha-muurolene, cuparene, gamma-cadinene, (Z)-3-heptadecene, 1,3,7,7-tetramethyl-2-oxabicyclo(4.4.0)dec-5-en-4-one, hexahydrofarnesyl acetone, gamma- elixene and palmitinic acid. The antimicrobial and antitumor activitiy of the E. macrorrhiza essential oil against Staphyloccocus aureus, Escherichia coli, Canidia Albicans and Caco-2 cells were evaluated. Among all the tested microorganisms and Caco-2 cells, the essential oils showed the strongest inhibitory effect on Staphyloccocus aureus (MIC = 2.8 mu g/mL) and Caco-2 cell (IC50 = 11.86 mu g/mL), whereas no effect on Escherichia coli and Candida albicans. The data of this study suggested that the E. macrorrhiza essential oils have great potential as a natural medicine for microbial infections and cancers.
KeywordEuphorbia Macrorrhiza Essential Oil Composition Antimicrobial Activity Antitumor Activity
Subject AreaChemistry
DOI10.3390/molecules17055030
Indexed BySCI
WOS IDWOS:000304587600022
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/1628
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lin Jianbo,Dou Jun,Xu Jiangling,et al. Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of Euphorbia macrorrhiza[J]. MOLECULES,2012,17(5):5030-5039.
APA Lin Jianbo,Dou Jun,Xu Jiangling,Aisa Haji Akber,&Aisa, HA.(2012).Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of Euphorbia macrorrhiza.MOLECULES,17(5),5030-5039.
MLA Lin Jianbo,et al."Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of Euphorbia macrorrhiza".MOLECULES 17.5(2012):5030-5039.
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