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学科主题: General & Internal Medicine (provided by Thomson Reuters)
题名: 鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响
其他题名: Effects of total saponins from Cicer arietinum L.on blood glucose and pancreatic pathology of type 2 diabetes mellitus rats
作者: 凯赛尔·阿不都克热木; 李治建; 李潇; 阿吉艾克拜尔·艾萨; 闫冬; 帕尔哈提·克里木
关键词: total saponins from Cicer arietinum(TSCA) ; type 2 diabetes mellitus ; glucose ; pancreatic ; pathological structure
刊名: 中药药理与临床
发表日期: 2011
DOI: 10.13412/j.cnki.zyyl.2011.03.020
卷: 27, 期:3, 页:47-49
资助者: 新疆维吾尔自治区自然科学基金
摘要: 目的:观察鹰嘴豆总皂苷(TSCA)对2型糖尿病大鼠血糖及胰腺病理结构的影响。方法:高糖高脂饲料喂养加链脲佐菌素(STZ)腹腔注射建立2型糖尿病大鼠模型。将造模成功大鼠随机分为模型组和鹰嘴豆总皂苷治疗组,灌胃给药,另设正常对照组,给药2周后,检测空腹血糖值(FPG)、并对胰腺组织进行病理学观察。结果:与模型组相比,鹰嘴豆总皂苷各剂量组均可有效降低2型糖尿病大鼠的血糖,对损伤的胰岛有一定的修复作用。结论:鹰嘴豆总皂苷各剂量组可有效降低2型糖尿病大鼠空腹血糖,并改善损伤胰岛的病理结构。
英文摘要: Objective:To study the effects of total saponins from Cicer arietinum L.(TSCA)on blood glucose and pancreatic pathology of type 2 diabetes mellitus(T2DM)rats.Methods:Established T2DM rats model with high calorie feeding and injection of STZ(45 mg/kg).T2DM rats were randomly assigned to model group and TSCA treat group.These two groups were treated with irrigate stomach.,Detected fasting glucose(FPG)and observed the pancreatic pathology 2 weeks after treating with TSCA.Result:Compared with model group,total saponins from Cicer arietinum L.can effectively reduce blood glucose in Type 2 diabetes mellitus rats,and can repair the damaged pancreatic pathology.Conclusion:The result suggests that TSCA could be used to reduce FPG and to repair the damaged pancreatic pathology of T2DM rats.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1574
Appears in Collections:资源化学研究室_期刊论文

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作者单位: 新疆医科大学药理学教研室;新疆维吾尔自治区维吾尔医药研究所;中国科学院新疆理化技术研究所

Recommended Citation:
凯赛尔·阿不都克热木,李治建,李潇,等. 鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响[J]. 中药药理与临床,2011,27(3):47-49.
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文件名: 鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响.pdf
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