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鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响
Alternative TitleEffects of total saponins from Cicer arietinum L.on blood glucose and pancreatic pathology of type 2 diabetes mellitus rats
凯赛尔·阿不都克热木; 李治建; 李潇; 阿吉艾克拜尔·艾萨; 闫冬; 帕尔哈提·克里木
2011
Source Publication中药药理与临床
ISSN1001-859X
Volume27Issue:3Pages:47-49
Abstract

目的:观察鹰嘴豆总皂苷(TSCA)对2型糖尿病大鼠血糖及胰腺病理结构的影响。方法:高糖高脂饲料喂养加链脲佐菌素(STZ)腹腔注射建立2型糖尿病大鼠模型。将造模成功大鼠随机分为模型组和鹰嘴豆总皂苷治疗组,灌胃给药,另设正常对照组,给药2周后,检测空腹血糖值(FPG)、并对胰腺组织进行病理学观察。结果:与模型组相比,鹰嘴豆总皂苷各剂量组均可有效降低2型糖尿病大鼠的血糖,对损伤的胰岛有一定的修复作用。结论:鹰嘴豆总皂苷各剂量组可有效降低2型糖尿病大鼠空腹血糖,并改善损伤胰岛的病理结构。

Other Abstract

Objective:To study the effects of total saponins from Cicer arietinum L.(TSCA)on blood glucose and pancreatic pathology of type 2 diabetes mellitus(T2DM)rats.Methods:Established T2DM rats model with high calorie feeding and injection of STZ(45 mg/kg).T2DM rats were randomly assigned to model group and TSCA treat group.These two groups were treated with irrigate stomach.,Detected fasting glucose(FPG)and observed the pancreatic pathology 2 weeks after treating with TSCA.Result:Compared with model group,total saponins from Cicer arietinum L.can effectively reduce blood glucose in Type 2 diabetes mellitus rats,and can repair the damaged pancreatic pathology.Conclusion:The result suggests that TSCA could be used to reduce FPG and to repair the damaged pancreatic pathology of T2DM rats.

KeywordTotal Saponins From Cicer Arietinum(Tsca) Type 2 Diabetes Mellitus Glucose Pancreatic Pathological Structure
Subject AreaGeneral & Internal Medicine (Provided By Thomson Reuters)
DOI10.13412/j.cnki.zyyl.2011.03.020
Indexed ByCSCD
CSCD IDCSCD:4275250
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/1574
Collection资源化学研究室
Affiliation新疆医科大学药理学教研室;新疆维吾尔自治区维吾尔医药研究所;中国科学院新疆理化技术研究所
Recommended Citation
GB/T 7714
凯赛尔·阿不都克热木,李治建,李潇,等. 鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响[J]. 中药药理与临床,2011,27(3):47-49.
APA 凯赛尔·阿不都克热木,李治建,李潇,阿吉艾克拜尔·艾萨,闫冬,&帕尔哈提·克里木.(2011).鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响.中药药理与临床,27(3),47-49.
MLA 凯赛尔·阿不都克热木,et al."鹰嘴豆总皂苷对2型糖尿病大鼠血糖及胰腺病理结构的影响".中药药理与临床 27.3(2011):47-49.
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