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植物雌激素抗肿瘤作用机制研究进展
Alternative Titleresearch progress on anti-carcinogenic mechanism of phytoestrogens
魏华波; 马海蓉; 王振华
2011
Source Publication食品科学
ISSN1002-6630
Volume32Issue:1Pages:274-277
Abstract

植物雌激素是一类植物来源具有雌激素活性的非甾族杂环多酚类天然化合物,但其雌激素活性较雌二醇低,具有类雌激素或抗雌激素效应,可产生双向调节作用,对激素相关性疾病具有广泛预防作用。近年来的流行病调查和实验室研究显示,植物雌激素具有预防和抑制乳腺癌、前列腺癌、子宫内膜癌、卵巢癌、结肠癌等肿瘤的作用,但其机制目前尚未完全阐明。本文就近几年植物雌激素防癌作用、抗肿瘤作用及其机制进行综述,为肿瘤的预防和治疗提供新的思路。

Other Abstract

Phytoestrogens are natural heterocyclic and phenolics compounds which are similar to estrogens structurally and functionally.Phytoestrogens have both estrogenic and anti-estrogenic activity,and have a two-way regulation ability and protective function from hormone-associated disease.In addition,experimental and epidemiological evidence has implied that phytoestrogens reduce the occurrence of cancer,and inhibit the growth and proliferation of tumor cells,including mammary cancer,prostate cancer,endometrial carcinoma,ovarian cancer,colon carcinoma,leukemia,and hepatic carcinoma and gastric cancer.However,the anti-tumor mechanism of phytoestrogens is still unclear.The review summarizes the current research progress on the role phytoestrogens plays in cancer prevention and tumor resistance and its mechanism.In our view,phytoestrogens are potential candidates to prevent and treat tumor.

Keyword植物雌激素 肿瘤转移 血管新生 细胞凋亡 抗氧化
Subject AreaPharmacology & Pharmacy (Provided By Thomson Reuters)
Indexed ByCSCD
CSCD IDCSCD:4262731
Citation statistics
Cited Times:5[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/1526
Collection省部共建新疆特有药用资源利用重点实验室
Affiliation新疆特种植物药资源教育部重点实验室石河子大学药学院;中国科学院新疆理化技术研究所;中国科学院干旱区植物资源化学重点实验室
Recommended Citation
GB/T 7714
魏华波,马海蓉,王振华. 植物雌激素抗肿瘤作用机制研究进展[J]. 食品科学,2011,32(1):274-277.
APA 魏华波,马海蓉,&王振华.(2011).植物雌激素抗肿瘤作用机制研究进展.食品科学,32(1),274-277.
MLA 魏华波,et al."植物雌激素抗肿瘤作用机制研究进展".食品科学 32.1(2011):274-277.
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