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Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents
Li Xiao-Xia; Bai Li-Hong; Wang Huan; Wang Jia; Huang Yan-Ping; Liu Zhao-Sheng
2012
Source PublicationJournal of Chromatography A
ISSN219673
Volume1251Issue:6Pages:141-147
AbstractMolecular crowding is a new approach to promoting molecular imprinting more efficiently. In this work, this concept was applied to the preparation of imprinted monoliths in the presence of molecular crowding agent for stabilizing binding sites and improving molecular recognition. The imprinted monolithic column was synthesized using a mixture of enrofloxacin (template), methacrylic acid, ethylene glycol dimethacrylate, and polystyrene (molecular crowding agent). Some polymerization factors, such as template-monomer molar ratio and the composition of the porogen, on the imprinting effect of resulting MIP monolith were systematically investigated. Moreover, a stoichiometric displacement model for retention was successfully applied to evaluate the interaction between the solute and the stationary phase. Compared with the MIP prepared by conventional polymerization, the molecular crowding-based monolithic MIPs showed higher selectivity. The results suggested that molecular crowding is a powerful strategy to increase the effect of molecular imprinting.
KeywordMonolith Molecularly Imprinted Polymer Molecular Crowding Molecular Recognition Enrofloxacin
Subject AreaBiochemistry & Molecular Biology ; Chemistry
DOI10.1016/j.chroma.2012.06.050
WOS IDWOS:000307428800017
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/1397
Collection省部共建新疆特有药用资源利用重点实验室
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China;Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China
Recommended Citation
GB/T 7714
Li Xiao-Xia,Bai Li-Hong,Wang Huan,et al. Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents[J]. Journal of Chromatography A,2012,1251(6):141-147.
APA Li Xiao-Xia,Bai Li-Hong,Wang Huan,Wang Jia,Huang Yan-Ping,&Liu Zhao-Sheng.(2012).Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents.Journal of Chromatography A,1251(6),141-147.
MLA Li Xiao-Xia,et al."Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents".Journal of Chromatography A 1251.6(2012):141-147.
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