Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents
Li Xiao-Xia; Bai Li-Hong; Wang Huan; Wang Jia; Huang Yan-Ping; Liu Zhao-Sheng
2012
发表期刊Journal of Chromatography A
ISSN219673
卷号1251期号:6页码:141-147
摘要Molecular crowding is a new approach to promoting molecular imprinting more efficiently. In this work, this concept was applied to the preparation of imprinted monoliths in the presence of molecular crowding agent for stabilizing binding sites and improving molecular recognition. The imprinted monolithic column was synthesized using a mixture of enrofloxacin (template), methacrylic acid, ethylene glycol dimethacrylate, and polystyrene (molecular crowding agent). Some polymerization factors, such as template-monomer molar ratio and the composition of the porogen, on the imprinting effect of resulting MIP monolith were systematically investigated. Moreover, a stoichiometric displacement model for retention was successfully applied to evaluate the interaction between the solute and the stationary phase. Compared with the MIP prepared by conventional polymerization, the molecular crowding-based monolithic MIPs showed higher selectivity. The results suggested that molecular crowding is a powerful strategy to increase the effect of molecular imprinting.
关键词Monolith Molecularly Imprinted Polymer Molecular Crowding Molecular Recognition Enrofloxacin
学科领域Biochemistry & Molecular Biology ; Chemistry
DOI10.1016/j.chroma.2012.06.050
WOS记录号WOS:000307428800017
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/1397
专题省部共建新疆特有药用资源利用重点实验室
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China;Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China
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Li Xiao-Xia,Bai Li-Hong,Wang Huan,et al. Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents[J]. Journal of Chromatography A,2012,1251(6):141-147.
APA Li Xiao-Xia,Bai Li-Hong,Wang Huan,Wang Jia,Huang Yan-Ping,&Liu Zhao-Sheng.(2012).Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents.Journal of Chromatography A,1251(6),141-147.
MLA Li Xiao-Xia,et al."Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents".Journal of Chromatography A 1251.6(2012):141-147.
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