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学科主题: Biochemistry & Molecular Biology ; Chemistry
题名: Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents
作者: Li Xiao-Xia; Bai Li-Hong; Wang Huan; Wang Jia; Huang Yan-Ping; Liu Zhao-Sheng
关键词: Monolith ; Molecularly imprinted polymer ; Molecular crowding ; Molecular recognition ; Enrofloxacin
刊名: Journal of Chromatography A
发表日期: 2012
DOI: 10.1016/j.chroma.2012.06.050
卷: 1251, 期:6, 页:141-147
资助者: Hundreds Talents Program of the Chinese Academy of Sciences National Natural Science Foundation of China
摘要: Molecular crowding is a new approach to promoting molecular imprinting more efficiently. In this work, this concept was applied to the preparation of imprinted monoliths in the presence of molecular crowding agent for stabilizing binding sites and improving molecular recognition. The imprinted monolithic column was synthesized using a mixture of enrofloxacin (template), methacrylic acid, ethylene glycol dimethacrylate, and polystyrene (molecular crowding agent). Some polymerization factors, such as template-monomer molar ratio and the composition of the porogen, on the imprinting effect of resulting MIP monolith were systematically investigated. Moreover, a stoichiometric displacement model for retention was successfully applied to evaluate the interaction between the solute and the stationary phase. Compared with the MIP prepared by conventional polymerization, the molecular crowding-based monolithic MIPs showed higher selectivity. The results suggested that molecular crowding is a powerful strategy to increase the effect of molecular imprinting.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1397
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China;Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

Recommended Citation:
Li Xiao-Xia,Bai Li-Hong,Wang Huan,et al. Preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents[J]. Journal of Chromatography A,2012,1251(6):141-147.
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文件名: preparation and characterization of enrofloxacin-imprinted monolith prepared with crowding agents.pdf
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